Ellen: You can go straight back to Hell, you ugly bitch.
That was Ellen before she blew up the hardware store (with the hell hounds in them) while dead Jo was lying in her arms. OMG this episode is sooo depressing!
Jo is dead. Ellen is dead. Bobby can’t walk. Another horseman has been raised. It’s more or less the Winchesters left.
The episode was titled aptly – “Abandon All Hope”.